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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 7115-Methyl-Benzofuro[3,2-b]quinoline Derivatives as...

5-Methyl-Benzofuro[3,2-b]quinoline Derivatives as DNA Binders

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Abstract:

Several derivatives of 5-methyl-benzofuro [3,2-quinoline (O-isostere of cryptolepine) were synthesized. Spectrometric experiments and molecular modeling indicated that these derivatives interacted with duplex DNA by intercalation binding mode. The derivatives with aniline substituent exhibited superior DNA binding affinity to that of lead compound 5-methyl-benzofuro [3,2-quinoline.

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Periodical:

Advanced Materials Research (Volume 711)

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73-78

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.711.73

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Online since:

June 2013

Authors:

Rui Fang Zhang, Rui Rui Zhang, Yu Jing Lu, Zhi Yun Du, Cheng Jie Fu, Zhi Kai Tang, Yan Xiong Fang, Kun Zhang

Keywords:

5-Methyl-benzofuro[3,2-b]quinoline, Cryptolepine, DNA Binder, Isostere

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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