Characterization of Lidocaine Transdermal Patches from Natural Rubber Latex

Abstract:

The mucous liquid of Hevea brasiliensis or Para rubber tree, called natural rubber latex (NRL), composes of cis-1,4-polyisoprene which can form a patch under suitable formulation. In this study, blank and 5% lidocaine-loaded NRL patches were formulated and then characterized for physicochemical properties as well as evaluated in vitro drug release and stability. The patches were observed for their appearances. Surface morphology of the patches was investigated using a SEM. XRD was employed to study the crystallinity of the drug, the patch, and the drug-loaded patch. The extractions of lidocaine-loaded patches were analyzed for drug contents by HPLC. In vitro drug release study was performed using modified Franz diffusion cells. The patches at initial preparation and after kept at 4, 25, and 45 °C for 3 months were investigated for the stability determination. The results suggested that NRL could be used as a main component in pharmaceutical transdermal patches with acceptable physicochemical properties. Lidocaine-loaded NRL patches provided desirable drug release but high storage temperatures could age the patches resulting in darken color and lower release amount.

• Periodical: Advanced Materials Research (Volume 747)
• Pages: 103-106
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.747.103
• Online since: August 2013
• Authors: Prapaporn Boonme, Hasleena Boontawee, Wirach Taweepreda, Wiwat Pichayakorn
• Keywords: Lidocaine, Natural Rubber Latex (NRL), Transdermal Patches

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