Production of Paclitaxel Loaded PLA-Lecithin Ultrasound Contrast Agents

Xiang Rui Yang; Shi Chao Wu; Zheng Qing Hou; Yan Ge Wang; Qian Jiang

doi:10.4028/www.scientific.net/AMR.749.318

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 749Production of Paclitaxel Loaded PLA-Lecithin...

Production of Paclitaxel Loaded PLA-Lecithin Ultrasound Contrast Agents

Abstract:

Drug loaded PLA (or PLGA) mirobubbles that combine properties of ultrasound imaging contrast agents and drug carriers suffer from low encapsulation efficiency and difficulty to destruction with diagnosis ultrasound. In this paper, a new type of multifunctional paclitaxel-loaded poly lactide-lecithin (PLA-lecithin) microbubbles has been developed with a method of ultrasonic double emulsion solvent evaporation (UDES) combined with lyophilization, and single-factor of ultrasonic time was studied to influence bubble size and drug loading efficiency. Bubbles were characterized to be well dispersed, with size of 300nm~2um, and showed increased ultrasound imaging on rabbit liver and heart after intravenous injection.

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Periodical:

Advanced Materials Research (Volume 749)

Pages:

318-321

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.749.318

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Online since:

August 2013

Authors:

Xiang Rui Yang, Shi Chao Wu, Zheng Qing Hou, Yan Ge Wang, Qian Jiang

Keywords:

Lecithin-Poly Lactid (PLA), Paclitaxel, Ultrasound Contrast Agent, Ultrasound Imaging

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