Enantiomeric Separation of 1-Phenyl-1-Propanol Using Calix[4]Arene-Capped β-Cyclodextrin-Bonded Silica Particles as Chiral Stationary Phase in Capillary Electrochromatography

Abstract:

A new type of calix [ arene-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy) propylsilyl-appended silica particles (C4CD-HPS) has been successfully used as chiral stationary phase (CSP) in capillary electrochromatography (CEC) for separation of enantiomers of 1-phenyl-1-propanol for the first time. C4CD-HPS contains a chiral selector with two recognition sites: calix [arene and β-cyclodextrin. Due to the cooperative functioning of the calix [arene and β-cyclodextrin, C4CD-HPS has exhibited excellent enantioselectivity for the enantiomers of 1-phenyl-1-propanol. After the multiple phenolic hydroxyl groups in the calix [arene moieties are ionized in the running buffer, the bonded stationary phase C4CD-HPS becomes negatively-charged to provide high electroosmotic flow (EOF) in CEC. Fast and high-resolution separation for enantiomers of 1-phenyl-1-propanol has been easily achieved on C4CD-HPS. This new type of chiral stationary phase has exhibited great potential for fast enantiomeric separations in CEC.

• Periodical: Advanced Materials Research (Volume 749)
• Pages: 304-308
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.749.304
• Online since: August 2013
• Authors: Jia Zhao, Jun Li, E.L. Yong, Yin Han Gong
• Keywords: Capillary Electrochromatography, Chiral Separation, Chiral Stationary Phase

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