Design, Synthesis and Biological Evaluation of Novel Anticancer Agent Sprio Indolone Compounds

Abstract:

Indolone is a kind of natural product which was widely existed in the animal bodies and plants, which possess varieties of biological activities, such as anti-bacterial, anti-tumor, anti-aging and anti-anxiety activities. As we all known that many sprio compounds which containing hetero atom such as O, N, S have good biological activities. In this paper, a series of spiro indolone derivatives was design with the combination of indolone and sprio scaffold, 6 novel target compounds were synthesized in 3 or 4 steps in 6%-17% overall yield, which were characterized by ¹H NMR and their biological activities on tumor cells growth inhibition on human hepatoma cell HePG2 and human leukemia cell K562 by MTT method were evaluated.

• Periodical: Advanced Materials Research (Volumes 781-784)
• Pages: 1240-1243
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.781-784.1240
• Online since: September 2013
• Authors: Jing Yu Li, Xiao Min Zhang, Bin Bin Song, Peng Yu, Kui Lu
• Keywords: Anticancer, MTT, Sprio Indolone Derivatives

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