Chiral Discrimination of the Diastereomeric Salts with (R)-Nipecotic Acid and Tartaric Acid Derivative

Xiao Xia Sun; Ying Chun Li; Xiao Xiao Zhuang; Yu Hu

doi:10.4028/www.scientific.net/AMR.781-784.135

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 781-784Chiral Discrimination of the Diastereomeric Salts...

Chiral Discrimination of the Diastereomeric Salts with (R)-Nipecotic Acid and Tartaric Acid Derivative

Abstract:

An effective resolving agent, (D)-dibenzoyl tartaric acid (2b), was screened to yield direct resolution of (S)- ethyl nipecotate (1) with high optical purity and yield. Molecular recognition was studied by 1H NMR, IR, DSC and single crystal diffraction of the pair of diastereomeric salts. The less-soluble salt formed a supra molecular structure by enantio differentiating self-assembly.

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Advanced Materials Research (Volumes 781-784)

Pages:

135-138

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.781-784.135

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Online since:

September 2013

Authors:

Xiao Xia Sun, Ying Chun Li, Xiao Xiao Zhuang, Yu Hu

Keywords:

Molecular Complex, Molecular Recognition, Resolution, R-Nipecotic Acid, Self-Assembly

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