Beware of Pseudo Matrix-Matched Standard Calibration Curve due to Matrix Effect on Sulfonamide Residue in Honey

Abstract:

Honey was a particular matrix with a variety of composition and origin, which lead to different degree of matrix effect on analytes. As a rule, the matrix-matched calibration curve from blank honey was adopted to quantifying analyte in a batch. This paper investigated matrix effect on sulfonamide in four honey samples by high-performance liquid chromatography hyphenated with mass spectrometry detection. The main goal was to check whether matrix-matched calibration curve obtained from a random blank honey could match the real samples in character within current recommended acceptance criteria. It was found that analyte recovery from true matrix-matched standard calibration curve ranged 87.7-117.3%, whereas recovery from surrogate matrix-matched calibration curves gave a very wide range from 54.3 to 150.2%, far beyond the acceptance criteria. So it was perhaps not feasible to use a surrogated blank sample to prepare matrix-matched calibration curve for quantifying analyte, particularly for largely diverse honey samples in a batch. To reduce error from inter-sample matrix effect, the best solution seemed to use internal standard or standard addition.

• Periodical: Advanced Materials Research (Volumes 781-784)
• Pages: 120-126
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.781-784.120
• Online since: September 2013
• Authors: Yan Hua Wang, Dong Mei Xu, Chia Hung Chen, Shuenn Ren Cheng, Guo Ping Chang-Chien
• Keywords: Honey, Matrix Effect, Matrix-Matched Standard Calibration Curve, Sulfonamide

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