Drug Release Mechanism of Fast Temperature-Responsive Soy Protein/PNIPAAm IPN Hydrogels

Abstract:

Fast temperature-responsive interpenetrating polymer network hydrogels based on soy protein and poly(N-isopropylacrylamide) (PNIPAAm) were prepared using the sodium bicarbonate (NaHCO₃) solutions as the reaction medium. The structure and properties were characterized using Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The bovine serum albumin (BSA) release behaviors and release mechanism were also investigated. The results show that the proposed hydrogels have high porous structures and have a fast release rate. The BSA release mechanism belongs to an anomalous transport and the Fickian contribution is dominant. The proposed hydrogels may have the potential applications in the field of biomedical materials such as in the controlled release of drugs.

• Periodical: Advanced Materials Research (Volumes 781-784)
• Pages: 803-807
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.781-784.803
• Online since: September 2013
• Authors: Yong Liu, Shou Lian Wei, Miao Chan Liao
• Keywords: Fast Response, Hydrogel, Poly (N-isopropylacrylamide), Soy Protein

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