A method to estimate the thermodynamic properties of Multi- component white gold alloys from those of constitutive binary alloys was proposed. The Miedema's theory and Chou model. were used to calculate the formation enthalpies of Au–Cu–Ni-Zn-RE alloys. The agreement between the calculation and experiment is reasonable. Formation enthalpies of Au–Cu–Ni-Zn-RE and relative stability of their intermetallic compounds were predicted with present method.