Sample Description of Diabetic Rats Treated with the Drug Pair of Astragalus and Chinese Yam by Using Multivariated Data Mapping Methods of R

Abstract:

The drug pair of Astragalus and Chinese yam is an effective Traditional Chinese Medicine (TCM) formula treating diabetes, but its mechanism of action is not explicit. In order to reveal its antidiabetic mechanism, we carried out metabonomics study on diabetic rats treated with drug pair of Astragalus and Chinese yam. Data obtained by using UPLC-Q-TOF/MS method were classified into five groups (normal control group, Model Group, Astragalus Group, Chinese yam Group and the drug pair of Astragalus and Chinese yam Group). R software was used for Principal Component Analysis (PCA), Sammon mapping, Kruskal-Wallis mapping (isoMDS) and Independent Component Analysis (ICA). The exported LC/MS data were processed by R. PCA, isoMDS and ICA function were used to perform preliminary metabonomics analysis of diabetic rata treated with drug pair of Astragalus and Chinese yam. These results indicated the capacity of multivariate data mapping methods in metabonomics data.

• Periodical: Advanced Materials Research (Volumes 791-793)
• Pages: 3-6
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.791-793.3
• Online since: September 2013
• Authors: Li Rong Wu, Zhong Feng Shi, Xiao Bao Jin, Wei Dong Gao, Jia Yong Zhu
• Keywords: Diabetes, Drug Pair of Astragalus, Drug Pair of Chinese yam, Metabonomics, R

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