Biological Evaluation of a Novel Angiotensin II AT1 Receptor Antagonist with Anti-Hypertensive and Anti-Tumor Effects

Ya Jing Da; Zhi Long Chen

doi:10.4028/www.scientific.net/AMR.803.113

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Biological Evaluation of a Novel Angiotensin II AT₁ Receptor Antagonist with Anti-Hypertensive and Anti-Tumor Effects
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 803Biological Evaluation of a Novel Angiotensin II...

Biological Evaluation of a Novel Angiotensin II AT₁ Receptor Antagonist with Anti-Hypertensive and Anti-Tumor Effects

Abstract:

A novel nonpeptide angiotensin II receptor 1 antagonist, compound 1, N-butyryl-N-[(2'-(2, 5-dihydro-5-oxo-1, 2, 4-oxadiazol-3-yl) biphenyl-4-yl) methy-L-Valine was investigated by receptor-binding studies and vivo experiments in spontaneously hypertensive rats and renal hypertensive rats. Furthermore, treatment with compound 1 significantly inhibited the viability of human breast cancer cell line and promoted apoptosis of the cancer cells. The compound had the effects of anti-hypertension and anti-cancer, which suggested that this new compound could be considered as a candidate for both novel anti-hypertensive and anti-cancer agent.

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Periodical:

Advanced Materials Research (Volume 803)

Pages:

113-117

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.803.113

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Online since:

September 2013

Authors:

Ya Jing Da, Zhi Long Chen

Keywords:

Angiotensin Ii, AT₁ Receptor, Breast Cancer, Hypertension, Tumor

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