Synthesis, Characterization and Antitumor Activities of Platinum(II) Complexes

Abstract:

In order to obtain the mixed isobutylamine /cyclopentylamine platinum complexes with chloride and oxalic acid ions as leaving groups. The title compounds were synthetised from potassiumtetrachloroplatinate(II) by the reaction with potassium iodide, cyclopentylamine, isobutylamine, silver nitrate, potassium chloride, potassium oxalate monohydrate. The complexes structure and component were characterized by elemental analysis, ESI-MS, 1H-NMR and IR and the anticancer activity were measured by MTT method. The results showed that its structure was consistent with the title compound and had inhibiting effect on the growth of tumor cell lines in vitro.

• Periodical: Advanced Materials Research (Volume 803)
• Pages: 145-148
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.803.145
• Online since: September 2013
• Authors: Qing Kun Wang, Shao Ping Pu, Yong Nian Li, Jian He, Jie Jin, Qi Zhang
• Keywords: Antitumor Activity, Characterization, Platinum Complex, Synthesis

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