Tanshinone IIA Rapid Analysis of Jingutongxiao Pills by Near-Infrared Spectroscopy

Abstract:

Traditional Chinese medicine(TCM) preparation has a long history in China，and now it is an important direction at the development of hospital preparations, because lacking of quality control technology, quality of the different production batch is not quite stable in the process of production. Therefore, to establish perfect, accurate, rapid quality evaluation method is the key to realize modernization of the traditional Chinese medicine preparation ^[1,2]. The paper establishes the quantitative analysis model for Tanshinone IIA in Jingutongxiao Pills by near-infrared spectral technology. Through the discussion of spectral wavelength, spectral pretreatment and principal component count, it was found that the second derivative combined with partial least squares (PLS) establishes a best quantitative calibration model. The correlation coefficient of calibration (R²)was 0.975 37, the Root Mean Square Error of Cross Validation (RMSECV) is 0.001 17 and the external prediction deviation (RMSEP) is 0.00174. It indicated that the near-infrared spectral technology could be used for rapid, accurate, nondestructive determination of Tanshinone IIA in Jingutongxiao Pills^[3,4].

• Periodical: Advanced Materials Research (Volumes 807-809)
• Pages: 2075-2078
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.807-809.2075
• Online since: September 2013
• Authors: Jing Wei Lei, Hai Yan Gong, Lei Li, Cai Xia Xie, Xiao Yan Duan, Zhi Hong Chen, Yan Bai
• Keywords: Jingutongxiao Pills, Near Infrared Spectroscopy (NIRS), Tanshinone IIA

References

[1] K . Feng , B . -L. Chen , W . Xie . HPLC Determ ination ofTanshinoneⅡAin Jingutongxiao Pills , J . Lishizhen Med Mater Med Res , vol. 18, May. 2007, p.1051.

[2] X. -J. Zhao ,S. -J. Wang,H. -L. Xia et al. Improvement of quality standard for jingutongxiao pills ,J. Drug Standards of China , vol. 10, Oct. 2009, p.230.

[3] W. -J. Yang and X. -F. Liu . Determination of tanshinoneⅡA in Jingutongxiao Pills by RP-HPLC,J. Journal of Modern medicine and health , vol. 25, Dec. 2009, p.1787.

[4] Y. Sun . Study on Applications for Near Infrared Spectroscopy Analyzing Technique in Petro-Chem icalField , . J . Shandong chemical industry . vol 39, Feb. 2010, p.27.

[5] S. -N. Zhang ,H. -L. Yang ,Z. -Q. Liu , et al. On-line monitoring the contents of avtive components in the solution for fufangdanshen dripping pills by near-infrared spectrosopy,J. Chin J Pharm Anal. vol 29, Feb. 2009, p.192.

[6] Y. Bai,W. Zhang,X. Wang. Quantitative analysis on Yiqing granule from differentmanufacturers by near infrared diffuse reflectance spectroscopy,J. Chin J Pharm. Anal. vol35, Feb. 2010, p.166.

[7] Y. - M. Li, J . -Y. Guo, Q. - X . Chen, et al. Non-destructive analysis of Belladonna powder, J. Life Sci Instrum, vol 8, Feb. 2009, p.50.

[8] A . -J. Zhang, N. Dan, G. - L. Zhao , Study of near infrared on-line detection for industrialization of Salvia miltiorrhizae extracting, J. Chin Tradit Herb Drugs, vol41, Feb. 2010, p.238.