Modeling and Simulation of Degradation for Biodegradable Polymer Based on Cellular Automata (CA)

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Abstract:

In this article a model based on cellular automata (CA) is proposed to simulate the degradation for biodegradable polymer. The transformational rule of this model is constructed based on the hydrolysis reaction, oligomer diffusion equations and the relationship between intensity and number average molecular weight of the polymer. Furthermore, polymer DLPLA plate corresponding to this CA model was carried out. The simulation shows the middle hollow result which is accordance with the experiment phenomenon. The molecular in the degradation process has good fit with the experiment data. It proves that the model in this article is right and can provide numerical lead for the designs of biodegradable polymer devices.

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Advanced Materials Research (Volumes 821-822)

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1019-1022

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September 2013

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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[1] A. Joshi, KJ Himmelstein. Journal of Controlled Release, Vol. 15 (1991), p.95–104.

Google Scholar

[2] RB Bell, CS Kindsfater. Journal of Oral and Maxillofacial Surgery, Vol. 64 (2006), p.31–39.

Google Scholar

[3] C. Liu, Z. Xia and J T Czernuszka. Trans IChemE, Part A, Chemical Engineering Research and Design, Vol. 85 (2007) No. 7, p.1051–1064.

Google Scholar

[4] K. Zygourakis, P.A. Markenscoff. Biomaterials, Vol. 17 (1996) No. 2, p.125–135.

Google Scholar

[5] N. Bertrand, G. Leclair and P. Hildgen. I.J. Pharmaceutics, Vol. 343 (2007) No. 1-2, pp.196-207.

Google Scholar

[6] I Grizzi, H Garreau, S Li and M Vert. Biomaterials, Vol. 16 (1995) No. 4, pp.305-311.

Google Scholar

[7] Y Wang, JZ Pan, XX Han, et al. Biomaterials, Vol. 29 (2008) No. 23, pp.3393-3401.

Google Scholar

[8] DF Farrar, RK Gillson. Biomaterials, Vol. 23 (2002) No. 18, p.3905–12.

Google Scholar

[9] M. Deng, J. Zhou, G. Chen, D. Burkley, Y. Xu, D. Jamiolkowski, T. Barbolt. Biomaterials. Vol. 26 (2005) p.4327–4336.

DOI: 10.1016/j.biomaterials.2004.09.067

Google Scholar