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On the Determination of Content of 10 - DABIII in Enshi’s Taxus Chinensis Var Mairei
Abstract:
Chemical semi-syntheticmethod for efficient low toxicity of paclitaxelanalogues is the hot issue quite a longtime in the present and the future of chemical, biological medicine and relatedinterdisciplinary researches. 10-DABIII is the main precursor semi-syntheticraw materials. Taking Enshi’s perennial natural taxus chinensis and taxuschinensis leaves of artificial cultivation as raw material to study the effectof different drying methods and extraction methods on the contents of 10-DABIII.Experimental results show that the 10-DABIII in the natural taxus chinensis ishigher than that of artificially cultivated taxus chinensis; different dryingmethods affect the amount of 10-DABIII, that is, by contrast, drying processingmethod in 50°Clow temperature is superior to drying in the shade of the nature, and microwaveextraction is more efficient than conventional solvent one. Knowing the contentof 10-DABIII in Enshi’s taxus chinensis can provide the necessary experimentaldata for rational utilization of taxus chinensis medicinal material resources, topromote Enshi’s local economic development.
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1055-1059
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September 2013
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© 2013 Trans Tech Publications Ltd. All Rights Reserved
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