An Acetylcholinesterase Biosensor Based on Platinum-Palladium Nanoparticles-Single Walled Carbon Nanotubes

Tao Zhou; Qing Zhou; Yun Yang

doi:10.4028/www.scientific.net/AMR.850-851.102

Paper Titles

An Investigation into the Conversion of Propylene Glycol to 2,4-dimethyl-1,3-dioxolane over an Acid Catalyst Using Gas Chromatography
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Comparative Research on Basic Composition and Processing Properties of Inulin and Inulin Granules
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Fabrication of Colloidal Crystals on Different Patterned Silicon Substrates by Self-Assembly Method
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Prediction of TC16 Alloy Deformation Behavior Based on BP Neural Network
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An Acetylcholinesterase Biosensor Based on Platinum-Palladium Nanoparticles-Single Walled Carbon Nanotubes
p.102

Preparation and Optical/Electrochemical Properties of Poly(3-bromothiophene)
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Research of Accelerated Corrosion Test Method of 7A04 Aluminium Alloy in Xisha Atmospheric Environment
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A Modified Drucker-Prager Criterion for Transversely Isotropic Geomaterials and its Numerical Implementation
p.115

Study of Co/ZrO₂ Catalysts in Fischer-Tropsch Synthesis
p.120

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An Acetylcholinesterase Biosensor Based on Platinum-Palladium Nanoparticles-Single Walled Carbon Nanotubes

Abstract:

A sensitive amperometric acetylcholinesterase (AChE) biosensor based on platinum-palladium nanoparticles (Pt-Pd NPs)-single-walled carbon nanotubes (SWCNTs) and chitosan (CS) modified glassy carbon electrode (GCE) is developed. The Pt-PdNPs-SWCNTs-CS nanocomposites offer an excellent electron conductivity, catalysis and hydrophilic surface for biomolecule adhesion. CS is used as a cross-linker to immobilize the AChE on the surface of Pt-PdNPs-SWCNTs-CS and as a protective membrane of the AChE biosensor. The biosensor shows favorable affinity to acetylthiocholine chloride. It exhibits good sensitivity, stability, reproducibility and low cost, thus providing a promising tool for analysis of enzyme inhibitors. More importantly, this study could provide a universal platform for meeting the demand of the effective immobilization enzyme on the electrode surface.