Efficacy Comparison of On-Site Preparation of 5%Lidocaine Niosome Dispersion and Benzocaine/Tetracaine Gel

Abstract:

Pain reduction from palatal injection was comparatively investigated by using topical anesthetics, 5% lidocaine encapsulated niosomes (LN) and 18%benzocaine/2%tetraciane gel (BZ). The LN was prepared chair-sidedly by an ultrasonic dental scaler with physicochemical evaluation. A pin-prick test on the palatal mucosa of 10 healthy subjects determined the onset and the effective time of LN to be 45 s (±17.3) with the mean effective time of 130.5 s (±57.5). The pain intensity during an actual palatal injection (cuspid region) was compared after the topical application of LN and BZ in another 23 healthy subjects, using a split-mouth design. The median injection pain VAS after the application of BZ was 3.5 cm, significantly higher than that after the application of LN (median = 2.0 cm, (p< 0.05). The present study confirmed the use of the ultrasonic dental scaler in enhancing the efficacy of lidocaine in pain reduction from palatal injection.

• Periodical: Advanced Materials Research (Volume 853)
• Pages: 237-242
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.853.237
• Online since: December 2013
• Authors: Aroonsri Priprem*, Jarin Paphangkorakit, Sucharat Limsitthichaikoon, Supanigar Ruangsri Sermswatsri, Waranuch Pitiphat, Preeyarat Thaiprasong, Panupong Patchadee
• Keywords: Lidocaine, Niosome, Pain, Visual Analog Scale

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