Stability of Gold Nanoparticles Functionalized with Aminoacids

Abstract:

While bio(organic-inorganic) compatibility and absence of cytotoxicity are crucial to create a successful nanocarrier for applications in biosensing and drug delivery, the study of its stability before commercialization is quite important. In the present work, the stability of gold nanoparticles (AuNPs) functionalized with L-Cysteine (Cys) and Cysteine-Glycine (Cys-Gly) was studied. The AuNPs surface modification with Cys and CysGly was performed to improve their biocompatibility and, after that, the stability of capped AuNPs was investigated. The synthetized AuNPs using 10 mM of cysteine and 20 mM of Cys demonstrated stability after 1 month of storage, while all other concentration ratios resulted in the formation of chain-like conglomerates. For AuNP capped with CysGly all modifier concentrations led to stable samples within 1 month of storage.

• Periodical: Advanced Materials Research (Volume 880)
• Pages: 253-258
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.880.253
• Online since: January 2014
• Authors: Mayra C. Ramirez-Camacho, I. Tusovskaya, Arturo Susarrey-Arce, Alexey Pestryakov*, Nina Bogdanchikova
• Keywords: Cysteine, Functionalization, Glycine, Gold, Gold Nanoparticles Stabilization, Nanoparticle, Sodium Citrate

References

[1] Andrea Majzik, et al., Gold Bulletin Volume 42 No 2 (2009).

[2] Silke Krol et al., Nano Lett., 2006, 6 (9), p.1933–(1939).

[3] M.C. Ramirez-Camacho, I. Tusovskaya, A. Susarrey-Arce, 4, A. N. Pestryakov, N. Bogdanchikova, Advanced Materials Research, 872 (2014) 94-105.

DOI: 10.4028/www.scientific.net/amr.880.253

[4] OV. Salata, Journal of Nanobiotechnology, 2 (2004) 1-6.

[5] M. Thomas, A. Klibanov, Proc. Natl. Acad. Sci. USA 100 (2003) 9138-9143.

[6] Thi Ha Lien Nghiem1, Thi Huyen La, Xuan Hoa Vu, et. al, Adv. Nat. Sci.: Nanosci. Nanotechnol. 1 (2010) 025009 (5pp).

[7] V. A. Sinani, D. S. Koktysh,B. -G. Yun, R. L. Matts, T. C. Pappas, M. Motamedi, S. N. Thomas, N. A. Kotov, Nano Lett. 3 (9) (2003) 1177-1182.

DOI: 10.1021/nl0255045

[8] Y. Zhang, N. Kohler, M. Zhang, Biomaterials 23 (2002) 1553–1561.

[9] Bin Kang, Megan A. Mackey, Mostafa A. El-Sayed, J. Am. Chem. Soc., 132 (2010), 1517–1519.

[10] Po C. Chen, Sandra C. Mwakwari, Adegboyega K. Oyelere, Nanotechnology, Science and Applications, 1 (2008) 45-66.

[11] Yu Pan et. a., Small, 2007, 3, No. 11, 1941 – (1949).

[12] Aurora Mocanu, Ileana Cernica, Gheorghe Tomoaia, Liviu-Dorel Bobos, Ossi Horovitz, Maria Tomoaia-Cotisel, Colloids and Surfaces A: Physicochem. Eng. Aspects, 338 (2009) 93–101.

DOI: 10.1016/j.colsurfa.2008.12.041

[13] G. Sonavane, K. Tomoda, K. Makino, Colloids Surf. B, 66 (2008) 274–280.

[14] E. E. Connor, J. Mwamuka, A. Gole, C. J. Murphy, M. D. Wyatt, Small, 1 (2005) 325–327.

[15] I. Willner, E. Katz, B. Willner, R. Blonder, V. Heleg-Shabtai and A.F. Bückmann, Biosens. Bioelectron., 12 (1997) 337–356.

DOI: 10.1016/s0956-5663(96)00065-6

[16] P. Tengvall, M. Lestelius, B. Liedberg and I. Lundstroem, Langmuir, 8 (1992) 1236–1238.

DOI: 10.1021/la00041a001

[17] Hui-An Weng, Ching-Chou Wu, Chun-Cheng Chen, Chia-Che Ho, Shinn-Jyh Ding, Journal of Materials Science: Materials in Medicine, 21 (5) (2010) 1511-1519.

[18] C. M. Goodman, C. D. McCusker, T. Yilmaz, V. M. Rotello, Bioconjugate Chem., 15 (2004) 897–900.

[19] Yu. Petrov, Clusters and small particles, Moscow, Nauka (1982) 298.

[20] Aurora Mocanua, Ileana Cernicab, Gheorghe Tomoaiac, Liviu-Dorel Bobosa, Ossi Horovitz, Maria Tomoaia-Cotisel, Colloids and Surfaces A: Physicochem. Eng. Aspects 338 (2009) 93.