A Comparable Study on the Effects of Pristine and Functionalized Single-Walled Carbon Nanotubes on Schwann Cells

Tong Qiu

doi:10.4028/www.scientific.net/AMR.886.63

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 886A Comparable Study on the Effects of Pristine and...

A Comparable Study on the Effects of Pristine and Functionalized Single-Walled Carbon Nanotubes on Schwann Cells

Abstract:

A comparable study on the effects of pristine and functionalized single-walled carbon nanotubes on schwann cells were conducted. Schwann cells were co-cultured with three types of SWNTs, purified raw SWNTs (C), hydroxyl purified SWNTs (C-OH) and carboxyl purified SWNTs (C-COOH) at 25μg/mL. C-COOH promoted the cell viability after 72h exposure and sustained its redox states by enhancing GPx expression. On the contrary, C and C-OH weaken the antioxidant activity due to the inhibition in main antioxidant enzymes and further led to the decline in cell viability. Carboxyl modification of the SWNTs helps to improve the biocompatibility of the SWNTs by strengthening the antioxidant ability.

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Periodical:

Advanced Materials Research (Volume 886)

Pages:

63-65

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.886.63

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Online since:

January 2014

Authors:

Tong Qiu*

Keywords:

Biocompatibility, Carbon Nanotube (CN), Redox States, Schwann Cell

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