Experimental Fabrication and Property Research of Thermo-Sensitive Organic-Inorganic Hybrid Nano-Microcapsule

Abstract:

A thermo-sensitive organic-inorganic hybrid nanomicrocapsule was synthesized by miniemulsion polymerization through introducing N-isopropyl acrylamide (NIPAM) monomer to the copolymer of styrene that coat around the octane droplet and 3-trimethoxysil propyl methacrylate (MPS). The penetration and releasing behavior of cresol red in this nanomicrocapsule nearby the critical temperature was investigated with ultravioletvisible spectroscopy. The results showed that both the introduction of NIPAM monomer and the temperature affect the loading and releasing of cresol red in nanomicrocapsule and the microcapsule exhibited a certain penetration rate above the critical temperature, but the penetration was inconspicuous below the critical temperature, denoting that this nanomicrocapsule could realize on-off type of environmental thermo-sensitive controlled absorption and release.

• Periodical: Advanced Materials Research (Volume 886)
• Pages: 75-79
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.886.75
• Online since: January 2014
• Authors: Qin Fang Lu, Yue Shang, Guo Rong Shan
• Keywords: Nanocapsules, Organic-Inorganic Hybrid, Penetrative Properties, Thermo-Sensitive

References

[1] Hou Wei, Yang Xiaoying, Zhang Qingwe, Liu Peiyi: Research on drug release profile of thermo sensitive polymers. Chin Pharm J, Vol. 38(11) (2003), pp.857-860.

[2] Deng Ziwei, Yi Changfeng, Xu Zushun: Application of thermosensitivity polymers based on poly(N-isopropylacrylamide). J Funct Polym, Vol. 17(2) (2004), pp.317-324.

[3] Matsumura Y, Iwai K: Synthesis and thermo-responsive behavior of fluorescent labeled microgel particles based on poly(N-isopropylacrylamide) and its related polymers. Polymer, Vol. 46(23) (2005), pp.10027-10034.

DOI: 10.1016/j.polymer.2005.08.050

[4] Saunders B R, Vincent B: Microgel particles as model colloids: theory, properties and applications. Adv Colloid Interf Sci, Vol. 80(1) (1999), pp.1-25.

DOI: 10.1016/s0001-8686(98)00071-2

[5] Chu Liangyin, Zhu Jiahua, Chen Wenmei, Yang Liu, Xiao Xincai, Li Yan: Progress of the study on thermo-responsive controlled-release microcapsule membranes. Chem Ind Enging Prog, Vol. 22(2) (2003), pp.135-139.

[8] Ni Kefan, Shan Guorong, Weng Zhixue: Penetrating properties of novel organic-inorganic hybrid nanocapsules. J Chem Ind Eng, Vol. 56(8) (2005), pp.1575-1579.

[9] Cao Zhihai, Shan Guorong: Comparison of formation mechanism of nanocapsules through miniemulsion polymerization in the presence or absence of N-isopropyl acrylamide. Chem J Chinese Universities, Vol. 29(1) (2008), pp.201-205.

[10] Niu Wenqiang, (Fu Guoq, Wu Junli), Shi Keyu, Yuan Zhi, He Binglin: Preparation and characterization of drug-loaded PLA/PEG/PLA triblock copolymer nanocapsules. Chem J Chinese Universities, Vol. 26(7) (2005), pp.1369-1371.

[11] Bao Decai, Zhang Qionggan, Liu Xiudong, Ma Xiaojun, Yuan Quan. Preparation of VE microcapsules and its controlled release characteristics. Acta Phys-Chim Sin, Vol. 20(2) (2004), pp.178-181.