Bioinformatics Analysis on Homology of CagM Protein in Helicobacter pylori Cag Pathogenicity Island

Abstract:

[Objective]This paper aims to make a bioinformatics analysis on the homology of cagM nucleotide sequence and protein sequence in Helicobacter pylori cag pathogenicity island, calculate the protein conservatism and evolutionary process, and research the functions of the protein. [Methods]Use Clustal W software to make multiple sequence analysis, edit the results with GeneDOC software, and detect the variable sites and homology.[Results] The homology between cagM gene and the nucleotide sequence of other HP bacterial strains in GenBank is 96%~98%, the homology between cagM gene and cagM gene is 98%~99%, so the nucleotide sequence and protein sequence have high conservatism.[Conclusion]CagM gene is very conservative and it plays an important role in the process of H. Pylori evolution; CagM gene is very conservative and it has important functions in helicobacter pylori; as an important means of bioinformatics, homology not only can calculate the protein conservatism and evolutionary process, but also can find the similar functions of the protein.

• Periodical: Advanced Materials Research (Volumes 926-930)
• Pages: 1081-1084
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.926-930.1081
• Online since: May 2014
• Authors: Li Ping Xie*, Ya Gao, Shu Wei Tian, Si He Shao
• Keywords: Bioinformatics, CagM Gene, CagM Protein, Helicobacter pylori, Homology

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