Bioinformatics Analysis on Subcellular Localization and Functional Site of CagM Protein in Helicobacter pylori Cag Pathogenicity Island

Abstract:

[Objective]This paper aims to make a bioinformatics analysis on the subcellular localization and functional site of CagM protein in helicobacter pylori cag pathogenicity island and further explore the functions of CagM protein. [Methods]Apply SubLoc v1.0 program to make the subcellular localization of this protein, and use TargetP program and PSORTb version 2.0.4 to make the verification and analysis; use ANTHEPROT 5.0, Gene3D Scan Sequence software and InterPro Scan software to analyze the functional site of CagM protein, and use DOG1.0 software for the drawing. [Results]CagM is a kind of secretory protein located in the periplasmic space rather than a membrane protein; CagM has many functional sites such as N-glycosylation site, protein kinase C phosphorylation site, tyrosine kinase phosphorylation site, and myristoylation acting site as well as many PDZ III binding sites. [Conclusion]As a kind of secretory protein located in the periplasmic space, CagM protein will become the substrate of many kinds of kinases after the translation and a series of modification, and after it is activated, it will participate in the signal transmission function and the assembly of IV type secretion system, which may play a role in the collection and assembly process of other proteins.

• Periodical: Advanced Materials Research (Volumes 926-930)
• Pages: 1085-1088
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.926-930.1085
• Online since: May 2014
• Authors: Li Ping Xie*, Yan Jun Xue, Shu Wei Tian, Si He Shao
• Keywords: Bioinformatics, Cag Pathogenicity Island, CagM Protein, Functional Site, Helicobacter pylori, Subcellular Localization

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