Detoxification Capabilities of Adsorbents for Artificial Liver Support Devices: A Comparison

Abstract:

Adsorption performances of activated carbon Norit RO 0.8, neutral resin Amberlite XAD-7, anion resin Dowex 1x4 and cation resin Dowex 50wx4 were investigated in detail for artificial liver support devices. Firstly, equilibrium adsorption experiments of these adsorbents to albumin, creatinine, bilirubin, tryptophan and cholic acid were conducted respectively. Then their adsorption capacities were obtained by curve fitting. The results indicate that activated carbon Norit RO 0.8 and anion resin Dowex 1x4 are two better adsorbents for removing toxins. Lastly, adsorption rate constants of activated carbon Norit RO 0.8 and anion resin Dowex 1x4 to all above solutes were studied with pseudo-first and second-order kinetic adsorption models. The results show that the toxin adsorption rate of anion resin Dowex 1x4 is faster than that of activated carbon Norit RO 0.8. The systematical experimental results in this paper are very important references for researchers in the field of blood purification based on adsorption technology.

• Periodical: Advanced Materials Research (Volume 936)
• Pages: 789-794
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.936.789
• Online since: June 2014
• Authors: Wei Ping Ding*, Li Li Zou, Ying Ying Pei, Si Jie Sun, Da Yong Gao
• Keywords: Adsorption, Artificial Liver, Equilibrium Isotherm, Kinetic Adsorption, Toxin

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