Synthesis and Characterization of Amphiphilic Copolymer Poly[2-(dimethylamino)ethyl methacrylate-co-methyl methacrylate]

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A novel, well-defined, amphiphilic block copolymer was synthesized by RAFT copolymerization of 2-(dimethylamino) ethyl methacrylate (DMAEMA) and methyl methacrylate (MMA). The polymer structure was characterized by 1H NMR , GPC and TEM. It was found that the stable spherical micelles with core-shell structure are formed and good solubility in water. The copolymer would have great potential in drug delivery systems.

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776-779

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June 2014

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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[1] W.Y. Seow, J.M. Xue, Y.Y. Yang: Biomaterials 28(2007), p.1730.

Google Scholar

[2] K.S. Soppimath, L.H. Liu, W.Y. Seow, S.Q. Liu, R. Powell, P. Chan, Y.Y. Yang: Adv Funct Mater 17(2007), p.355.

Google Scholar

[3] E.S. Lee, K. Na, Y.H. Bae: Nano Lett 5(2005), p.325.

Google Scholar

[4] Y.Z. Wang, L. Yu, L.M. Han, X.Y. Sha, X.L. Fang: Int J Pharm 337(2007), p.63.

Google Scholar

[5] J. Wang, R. Wang, L.B. Li: J Colloid Interface Sci 336(2009), p.808.

Google Scholar

[6] D. Velluto, C. Wandrey, D. Demurtas, J. Dubochet: J Control Release 137(2009), p.146.

Google Scholar

[7] Y. Yang, J.C. Wang, X. Zhang, W.L. Lu, Q. Zhang: J Control Release 135(2009), p.75.

Google Scholar

[8] C.F. Mu, P. Balakrishnan, F.D. Cui, Y.M. Yin, Y.B. Lee, H.G. Choi: Biomaterials 31(2010), p.2371.

Google Scholar

[9] S.D. Li, L. Huang : Mol Pharm 5(2008), p.496.

Google Scholar

[10] C.M. Hu, L.F. Zhang : Curr Drug Metab 10(2009), p.836.

Google Scholar

[11] S. Dai, P. Ravi, K.C. Tam: Soft Matter 4(2008), p.435.

Google Scholar

[12] B.Y. Zhang, W.D. He, W.T. Li, L.Y. Li, K.R. Zhang, H. Zhang: Polymer 51(2010), p.3039.

Google Scholar

[13] S.M. Timol, D. Jhurry: Eur Polym J 43(2007), p.3042.

Google Scholar

[14] J. Chen, M.Z. Liu, N.Y. Zhang, P.P. Dai, C.M. Gao, L.W. Ma, H.L. Liu: Sens Actuators B 149(2010), p.34.

Google Scholar

[15] A. Naoto, E. Takeshi: Journal of Polymer Science: Part A: Polymer Chemistry, 47(2009), p.3702.

Google Scholar