Synthesis and Performance of pH-Sensitive Hydrogel Microspheres and In Vitro Evaluation as Potential Drug Carriers

Abstract:

To accelerate the response rate of smart hydrogels to the environmental conditions, a novel pH-sensitive hydrogel microsphere with the controlled shapes and sizes were developed. Such monodispersed microspheres were synthesized via free radical polymerization under the protection of a multilayer stability system. The pH-responsibility of hydrogel microspheres was tested with the hydrogel bulk as a control. In vitro release studies were conducted in the simulated gastric fluid and intestinal juice with bovine serum albumin (BSA) as a model drug. The large specific surface areas endowed hydrogel microspheres a faster pH-responsibility than that of bulk ones. Therefore, such microspheres showed potential applications as the oral protein drugs carrier.

• Periodical: Advanced Materials Research (Volume 936)
• Pages: 751-756
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.936.751
• Online since: June 2014
• Authors: Yuan Yuan Liang, Tong Chen, Yu Qin Cui, Rui Qiong Tian, Tong Sheng Qi, Qing Shang*
• Keywords: BSA, Hydrogel Microspheres, pH-Sensitive, Swelling Behaviour

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