Preparation and Anti-Tumor Activity of Polysaccharides from Phellinus pini Mycelia

Abstract:

Polysaccharides PSIand PSIIwere isolated from liquid-cultured mycelia of Phellinus pini. The average molecular weight: PSI36 kDa, PSII49 kDa; sulfate content: PSI5.25%, PSII0.65%; monosaccharide composition: PSIglucose, galactose and mannitose; PSIIglucose, mannitose and xylose. Anti-tumor activities of PSIand PSII(400 mg/kg·d, i.g.) were investigated in S180-bearing mice. Results indicated that PSIand PSIIsignificantly inhibited the growth of S180-solid tumors. PSIand PSIIeffectively protected immune organs (thymus and spleen) and increased activities of immune cells (NK cells, macrophages, T and B lymphocytes). Results suggest that polysaccharides PSIand PSIIfrom Phellinus pini have potential anti-tumor activities, which might attributed partly to their immunomodulatory properties.

• Periodical: Advanced Materials Research (Volume 936)
• Pages: 728-733
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.936.728
• Online since: June 2014
• Authors: An Jun Liu, Hong Chen Sun, Ying Chen*, Wen Hang Wang, Cai Hong Liu, Yue Meng Wang
• Keywords: Anti-Tumor Activity, Phellinus pini, Polysaccharide, Preparation

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