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Preparation and Drug Release Behavior of IPN Hydrogel of Polyethylene Glycol and Octane Succinyl Chitosan

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Abstract:

The octane-succinyl-chitosan (C8-SCCHS) was synthesized by modifying chitosan (CHS) , characterized by IR, 1H NMR, WAXD and octane-succinyl-chitosan/polyethylene glycol (C8-SCCHS)/PEG interpenetrating polymer network (IPN) hydrogel was prepared by croslinking of C8-SCCHS and PEG. The swelling behaviors of hydrogels in different pH solutions have been studied. The pH sensibility were researched. Micromorphology of the external surface of the hydrogels were imaged by scanning electron microscopy (SEM). Aciclovir as a model drug to study the performance of their release. The results show that the gels have porous cross-linked network structure, which is beneficial to absorbing water or drug, and have ability of controlled release for aciclovir.

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Periodical:

Advanced Materials Research (Volumes 941-944)

Pages:

1216-1220

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.941-944.1216

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Online since:

June 2014

Authors:

Fu Neng Tan*, Yuan Yuan He, Wei Ping Sui

Keywords:

Drug Release, Hydrogel, Octane-Succinyl-Chitosan, Polyethylene Glycol

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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