Community Based Environmental Risk Analysis for Ciprofloxacin Hydrochloride

Abstract:

The negative effects of pharmaceuticals residues in aquatic environment to organisms have been attracted more and more attention in the public. In this paper, the effects of ciprofloxacin hydrochloride on community of aquatic organisms were analyzed. The acute toxicity values (EC50/LC50) for Chlorella vulgaris, Photobacterium phosphoreum, Daphnia magna and guppy were 20.61、63.27、135.15 and 365.00 mg/L respectively. The results showed that the higher chain level of organism could lead to stronger tolerance of ciprofloxacin hydrochloride. Standardization Risk Quotient (SRQ) was proposed basing on the introduction of the normalization factor into risk models. SRQ can be directly applied to judge the risk levels for the exogenous pollutants into the environment without considering the effects of aquatic organisms from different food chains.

• Periodical: Advanced Materials Research (Volumes 955-959)
• Pages: 297-301
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.955-959.297
• Online since: June 2014
• Authors: Ying Hui Zhao, Yu Ying Dong*, Xue Jun Zou, Chun Hua Zhang, Yu Bo Cui
• Keywords: Acute Toxicity, Aquatic Organisms, Ciprofloxacin Hydrochloride, Community, Standardization Risk Quotient

References

[1] T J Xia, X F Xia, Y D Xu, et al., Determination of the residual tetracycline antibiotics in the manures of livestock via the solid-phase extraction-high performance liquid chromatography method, Journal of Safety and Environment. 13 (2013).

[2] M D Burke, A Cunha, Antibiotic side effects, Medical Clinics of North America. 85 (2001) 149–185.

DOI: 10.1016/s0025-7125(05)70309-6

[3] Z J Kuang, Side Effects of Ciprofloxacin, Guangdong Weiliang Yuansu Kexue. 8 (2001) 15-20.

[4] X Wang, X P Nie, K B Li, Acute toxicity of CPFX and TCCA to Aquatic Organisms, Ecologic Science. 25 (2006) 155-157.

[5] Y Y Dong, B P Lei, J Ma, et al., Influence of cosolvents on Photobacte rium phosphoreum toxicity test, Journal of Chemical Industry and Engineering. 57 (2006) 635-639.

[6] Y C Fang, Y Qi, Y Li, et al., Acute Toxicity Experience to Guppy with Ciprofloxacin HCI, Enrofloxacin and Norfloxacin, Journal of Shenyang University. 24 (2012) 15-17.

[7] V L Cunningham, D J Constable, R E Hannah, Environmental risk assessment of paroxetine, Environ Sci & Technol. 38 (2004) 3351-3359.

DOI: 10.1021/es035119x

[8] P H Marie, A Rortais, G Arnold, et al., New risk assessment approach for systemic insecticides: the case of honey bees and imidacloprid, Environ Sci & Technol. 40 (2006) 2448-2454.

DOI: 10.1021/es051392i

[9] Y Y Dong, X J Zou, Z Chen, et al., Joint toxicity and environmental risk analysis of three common pharmaceuticals, Environmental Chemistry. 32 (2013) 1257-1262.

[10] D A Paul, J D Vincent, S Peter, et al., Screening analysis of human pharmaceutical compounds in U. S. surface waters, Environ Sci & Technol. 38 (2004) 838-849.

[11] B P Lei, S B Huang, Z J Wang, Theories and Methods of Ecological Risk Assessment, Progress in Chemistry. 21 (2009) 350-358.

[12] H Ren, J R Wang, X J Chen, et al., Primary Research on Single and Combined Toxicity of Antibiotics in Feeds by Luminescent Bacteria, Feed Processing and Testing. 47 (2011) 49-52.

[13] W A Tauxe, D L F Alencastro, D Grandjean, et al., Occurrence of several acidic drugs in sewage treatment plants in Switzerland and risk assessment, Water Research. 39 (2005) 1761-1772.

DOI: 10.1016/j.watres.2005.03.003

[14] E M Golet, A C Alder, W Giger, Environmental exposure and risk assessment of fluoroquinolone antibacterial agents in wastewater and river water of the Glatt Valley Watershed, Switzerland, Environ Sci & Technol. 36 (2002) 3645-3651.

DOI: 10.1021/es0256212

[15] Y Y Dong, Y Zhang, Y Cao, Screening analysis of pharmaceutical substances with high risk in water body based on comprehensive risk assessment, Joumal of Southwest University for Nationalities-Natural Science Edition. 34 (2008) 115-119.