Research Progress in the Typical Structure of Human Telomeric G-Quadruplex

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Abstract:

Telomeric DNA of human chromosomes plays a significant role in physiological processes such as cell cycle, aging, cancer and genetic stability due to its special sequence and structure. The research on small molecule ligands targeting G-quadruplex formed by such special sequence has attracted considerable attention, and has achieved great breakthrough. In this paper, we summarize the DNA sequences and structures of three kinds of typical human telomeric G-quadruplex, providing an important reference for further research.

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Advanced Materials Research (Volumes 955-959)

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419-422

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June 2014

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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