Small Natural Molecules Targeting DNA G-Quadruplexes

Zi Jian Li; Yan Ping Ding; Su Lin Zhang; Yan Ling Wu; Wen Zhang

doi:10.4028/www.scientific.net/AMR.955-959.423

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The Characteristics of the Rare Earth Elements in the Surface Sediments on the Western South Yellow Sea
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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 955-959Small Natural Molecules Targeting DNA...

Small Natural Molecules Targeting DNA G-Quadruplexes

Abstract:

DNA G-quadruplex (G4-DNA) has emerged as a new drug target for anti-tumor. The small compounds can induce the formation of G4-DNA and stabilize its structures, which is of potential significance for the tumor treatment. This paper focuses on our current understanding about the structure of G4-DNA, the binding mode between G4-DNA and small molecular ligands, and natural products targeting G4-DNA.

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Periodical:

Advanced Materials Research (Volumes 955-959)

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423-426

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.955-959.423

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Online since:

June 2014

Authors:

Zi Jian Li, Yan Ping Ding, Su Lin Zhang, Yan Ling Wu, Wen Zhang

Keywords:

Binding Mode, DNA G-Quadruplex, Natural Product, Small Molecule

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