Minute vibration of grinding wheel greatly restricts machining accuracy of axisymmetric aspheric surface in precision grinding. This paper is dedicated to analysis micro-topography of grinding surface under grinding wheel vibration. The relative motion track of wheel to ideal lens surface and the interference of them are involved to study the effects of grinding wheel vibration on surface quality. For different operation parameters, the processed surface presents various micro-topography, and the restriction extent of vibration to surface quality is also different. Vibration waveform in the region near lens center is smoothed greatly by the interference of wheel and the processed surface. Therefore, surface quality gets some improvement from edge to center for axisymmetric aspheric lens. Experiment results verified the validity of the theoretical analysis.