This article explored the design method of the wind turbine blade being of flapping-twist adaptive performance and how to evaluate its feasibility and reliability according to the comprehensive factors. The results indicate that both spar cap and skin with off-axis carbon fiber can achieve the efficient flapping-twist coupling effect. Through overall investigation, the results show that the maximum fiber strains of tensile and compressive go up with increase of the off-axis angle, and the peak inter-laminar shear stress increase more rapidly. While, all of these evaluating indicators should be kept in the reference range for used materials. Moreover, when the off-axis angle increases, the peak Von Mises stress declines. In addition, the impact of natural frequencies on the blade design is proved to be insignificant. Finally, utilizing the medial axis laminates in the blade decoupled area is helpful to strengthen the blade fatigue resistivity.