In order to increase the efficiency of machine tools, the development of machine tools is toward higher speed and accuracy. The higher speed of spindle causes more thermal deformation, which reduces the accuracy of machine tools. In this study, finite element method is used to simulate the thermal deformation of spindle caused by the friction loads between spindle and bearings. The bearing load is estimated by the basic load rating from the bearing vendor and the required life of bearing. The simulated results are compared with experimental measurements to verify the analysis model. The result shows that the stabilized temperature of spindle increases as the speed increaser, while the stabilized displacement of spindle slightly increases as the speed increases.