Inhibition of Sodium Citrate on Aggregation and Sedimentation of Nanocalcium Oxalate Dihydrate Crystals

Meng Xu; Jun Fa Xue; Jun Jun Li; Xiao Ling Wen; Jian Ming Ouyang

doi:10.4028/www.scientific.net/AMR.988.75

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 988Inhibition of Sodium Citrate on Aggregation and...

Inhibition of Sodium Citrate on Aggregation and Sedimentation of Nanocalcium Oxalate Dihydrate Crystals

Abstract:

Objectives: The effects of sodium citrate (Na₃cit) on sedimentation and aggregation of calcium oxalate dihydrate (COD) nanocrystallites with a size of about 50 nm was studied in order to explore the mechanism of Na₃cit to inhibit calcium oxalate stone formation. Methods: The influence of concentration of Na₃cit (c(Na₃cit)) on size, Zeta potential, aggregation, and sedimentation of COD nanoparticles in aqueous solution was studied using nanoparticle size Zeta potential analyzer and ultraviolet spectrophotometer. Results: In low c(Na₃cit) (< 0.8 mmol/L), the inhibition effect of Na₃cit on aggregation and sedimentation of nanoCOD increased with the increase of c(Na₃cit); while in high c(Na₃cit), COD was gradually dissolved by Na₃cit. The former was due to the specific adsorption of citrate ions (cit^3-) on COD surface, which made the absolute Zeta-potential increased, therefore inhibited the aggregation and sedimentation of nanocrystallites; the later was because the high concentration of cit^3- made Ca²⁺ ions dissociated from the crystal surface, leading to COD dissolution. Conclusions: Na₃cit can inhibit the aggregation and sedimentation of nanoCOD in low concentration and dissolve COD in high concentration, indicating that Na₃cit can inhibit the formation of calcium oxalate stones.

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Periodical:

Advanced Materials Research (Volume 988)

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75-78

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.988.75

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Online since:

July 2014

Authors:

Meng Xu, Jun Fa Xue, Jun Jun Li, Xiao Ling Wen, Jian Ming Ouyang*

Keywords:

Calcium Oxalate Dihydrate, Nanocrystal, Sodium Citrate Crystallite Aggregation

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