Towards In Vivo Nanomachines

Abstract:

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DNA has been recently used to construct a variety of nanoscale machines and switches, among them devices which can translocate, compute, or bind and release molecules. For future applications it is interesting to investigate whether these "artificial" functions can also be implemented in vivo. As one step towards in vivo applications, we currently utilize RNA molecules for construction or control of molecular devices. RNA molecules can be transcribed from "artificial genes" and either fold into functional nanoassemblies themselves or drive other nucleic acid-based devices as a "fuel". Furthermore, coupling of nanomachines to RNA transcription enables control of their behavior using gene regulatory motifs.

Info:

Periodical:

Edited by:

Pietro VINCENZINI and Salvatore GRAZIANI

Pages:

120-126

DOI:

10.4028/www.scientific.net/AST.58.120

Citation:

E. Friedrichs et al., "Towards In Vivo Nanomachines", Advances in Science and Technology, Vol. 58, pp. 120-126, 2008

Online since:

September 2008

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Price:

$35.00

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