Hepatocellular Effect of Copper Poisoning on the Liver and Kidney of Albino Rats (Rattus norvicus)

Abstract:

Copper and its salt are remarkably non-toxic to mammalian tissue. It is possible to ingest a large number of soluble copper salts such as copper sulphide to produce intoxication, nausea, vomiting, diarrhoea, and abdominal cramp. Copper salts are widely employed in agriculture and veterinary practice. Copper is an essential trace element in life and is a component of several metalloenzymes and other proteins such as cytochrome oxidase, heamocyanin, lysin oxidase, ascorbate oxidase and amine oxidase. When copper is present in the body above a particular dosage of greater than 100ppm in rats, it becomes fatal to rats. Copper is transported by blood, and is distributed to tissue and organs which have different retention capacities with the highest level of copper found in the liver, kidney, spleen and lungs. This study investigated the toxicological effect of copper in the liver and kidney of animals, using albino rats as the experimental animal. The serum chemistry report showed that the protein value of the liver homogenate for most of the experimental rats was higher than that of the control whereas the value of globulin for the control was similar to that of the experimental rats. The kidney homogenate revealed that Calcium ion has higher contents in the experimental rats than that in the control. In conclusion, the effect of copper varies with the groups of rats as compared to the control.

• Periodical: Engineering Headway (Volume 2)
• Pages: 29-37
• DOI: https://doi.org/10.4028/p-vzG5cJ
• Online since: January 2024
• Authors: Oyetunde Opanike, Olugbenga A. Omotosho, Emmanuel O. Akindele, Omolola O. Yusuf*
• Keywords: Albino Rats, Albumin, Cholesterol, Copper, Creatinine, Protein, Serum, Toxicity

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