Paper Titles
Overview of Progress in Development of the Bionic Underwater Propulsion System
p.9
A Method for Optimal Synthesis of a Biomimetic Four-Bar Linkage Knee Joint for a Knee-Ankle-Foot Orthosis
p.20
A Three Dimensional Finite Element Analysis of Mechanical Stresses in the Human Knee Joint: Problem of Cartilage Destruction
p.29
Biomechanical Comparison between Two Models of the Lumbar Intersomatic Fusion Cage Analyzed by the Finite Element Method
p.40
The Effect of Sintering Temperature to the Quality of Hydroxyapatite Coating on Cobalt Alloys as the Candidate of Bone Implant Prosthesis
p.59
Eggshell Membrane Protein Modified Silk Fibroin-Poly Vinyl Alcohol Scaffold for Bone Tissue Engineering: In Vitro and In Vivo Study
p.69
Composite of Chitosan-Collagen-Aloe vera for Scaffolds Application on Skin Tissue
p.82
PLGA-Collagen Composite Synthesis with the Antibacterial Addition of Jatropha curcas L. Leaf Extract as Absorbable Surgical Suture Candidate
p.90
Prediction of Phagocyte Transmigration for Foreign Body Responses to Subcutaneous Biomaterial Implantations Using Differential Transform Method
p.98

PLGA-Collagen Composite Synthesis with the Antibacterial Addition of Jatropha curcas L. Leaf Extract as Absorbable Surgical Suture Candidate

Article Preview

Abstract:

The prevalence rate of surgical wound infections caused by bacteria is an average of 9% of the 1.4 million patients worldwide. For this reason, a modification of an absorbable surgical suture coated with extract of Jatropha curcas L. leaves to kill and inhibit the growth of microorganisms needs to be made. The forming of multifilament fibers is done by electrospinning method. The test results of the functional groups showed the presence of interaction between PLGA-Collagen with the extract of Jatropha Curcas L. leaves indicated by an absorption band at 2924 cm-1 which showed the vibrations of C-H. The tensile test results showed that all samples were in the range of 19.5-87.1 MPa values which corresponded with the modulus of elasticity of the suture thread in the forehead and elbows. The MTT Assay results showed that the percentage of living cells of all samples was above 50%. The bacterial activity test showed that the inhibition zone were in the range of 5-10 mm. The optimal sample showed the degradation rate of 82.2% on the 60th day of the soaking period. It can be concluded that PLGA-collagen Jatropha curcas L. extracts is safe composite and has potential as antibacterial absorbable surgical sutures.

You might also be interested in these eBooks
Journal of Biomimetics, Biomaterials and Biomedical Engineering Vol. 32 View Preview

Info:

Periodical:

Journal of Biomimetics, Biomaterials and Biomedical Engineering (Volume 32)

Pages:

90-97

DOI:

https://doi.org/10.4028/www.scientific.net/JBBBE.32.90

Citation:

Cite this paper

Online since:

May 2017

Authors:

Karina Dwi Saraswati, Prihartini Widiyanti*, Dwi Gustiono, Jan Setiawan

Keywords:

Absorbable, Jatropha curcas L. Leaf Extracts, PLGA, Surgical Suture

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2017 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

* - Corresponding Author

References

[1] Potter, P.A., dan Perry, A.G. 2005b. Buku Ajar Fundamental Keperawatan: Konsep, Proses, dan Praktik. Vol. 2. Edisi 4. Alih Bahasa oleh Renata Komalasari et al. Jakarta: EGC.

Google Scholar

[2] Kusumayanti, et al,. 2013. Faktor-Faktor yang Berpengaruh Terhadap Lamanya Perawatan pada Pasien Pasca Operasi Laparatomi di Instalasi Rawat Inap Brsu Tabanan. Jurnal Fakultas Kedokteran, Universitas Udayana, Indonesia.

DOI: 10.55045/jkab.v10i2.128

Google Scholar

[3] Mazzocca, Augustus D., et al. 2007. Tendon and bone responses to a collagen-coated suture material. J Shoulder Elbow Surg. Sep-Oct; 16(5 Suppl): S222-30. Epub 2007 Apr 19.

DOI: 10.1016/j.jse.2007.02.113

Google Scholar

[4] Almubarak, Luluah. 2013. Cutaneous Wound Closure Materials : An Overview and Update. J Cutan Aesthet Surg. 2013 Oct-Dec; 6(4): 178–188.

DOI: 10.4103/0974-2077.123395

Google Scholar

[5] Lee, Hye Sun, et al. 2013. Antimicrobial and biodegradable PLGA medical sutures with natural grapefruit seed extracts. Materials Letters 95 (2013) 40–43.

DOI: 10.1016/j.matlet.2012.12.090

Google Scholar

[6] K. S. Silvipriya, K. Krishna Kumar, A. R. Bhat, B. Dinesh Kumar, Anish John, Panayappan lakshmanan, 2015. Collagen: Animal Sources and Biomedical Application Journal of Applied Pharmaceutical Science Vol. 5 (03), pp.123-127, March, (2015).

DOI: 10.7324/japs.2015.50322

Google Scholar

[7] Ehsan Oskoueian, Norhani Abdullah, Syahida Ahmad, Wan Zuhainis Saad 1, Abdul Rahman Omar, Yin Wan Ho, 2011. Bioactive Compounds and Biological Activities of Jatropha curcas L. Kernel Meal ExtractInt. J. Mol. Sci. 2011, 12, 5955-5970.

DOI: 10.3390/ijms12095955

Google Scholar

[8] Izuogu, N.B., et al., 2013. The Potency of Moringa oleifera and Jatropha curcas Leaf extracts as Control for Root - Knot Nematode in Maize (Zea mays). International Journal of Phytofuels and Allied Sciences, September 2013, 2(1), 116-124.

Google Scholar

[9] Thermo Nicolet. 2002. Introduction to Fourier Transform Infrared Spectrometry. Thermo Nicolet Corporation All rights reserver, Worldwide, www. thermonicolet. com.

Google Scholar

[10] Gallagher, A. J et al. 2012. Dynamic Tensile Properties of Human Skin. IRCOBI Conference.

Google Scholar

[11] Spielmann H, et. al. 2007. The practical application of three validated in vitro embryotoxicity tests. ATLA, 527-538.

Google Scholar

[12] Mutia, Theresia et al. 2011. Alginates Membrane As Primary Wound Dressing And Topical Drug Delivery System For Infected Wound. Jurnal Riset Industri Vol. V, No. 2, 2011, Hal 161 -174.

Google Scholar

[13] Wittaya, Thawien. 2013. Influence of Type and Concentration of Plasticizers on the Properties of Edible Film from Mung Bean Proteins. KMITL Science and Technology Journal Vol 13, no. 1.

Google Scholar

[14] Ukunowo, Wahab O, et al. 2013. Essential Oil of Grape Fruit (Citrus paradisi) Peels and Its Antimicrobial Activities. American Journal of Plant Sciences, 2013, 4, 1-9.

DOI: 10.4236/ajps.2013.47a2001

Google Scholar

[15] Namuli, Aidah, et al., 2014. Membrane Active Antibacterial Compounds in Methanolic Extract of Jatropha curcas and their Mode of Action against Staphylococcus aureus S1434 Escherichia coli E216. INTERNATIONAL JOURNAL OF AGRICULTURE & BIOLOGY ISSN Print: 1560–8530; ISSN Online: 1814–9596.

Google Scholar

[16] Polleto, Matheus, et al. 2014. Native Cellulose: Structure, Characterization and Thermal Properties. Materials 2014, 7(9), 6105-6119.

Google Scholar