Organic Solvent Traces in Fibrillar Scaffolds for Tissue Engineering

Abstract:

In the present study the amount of xylene remaining in fibrillar scaffolds after their manufacture has been estimated by means of Gas Chromatrography coupled to Mass Spectrometry (GC-MS). For this purpose model scaffolds of poly(ethylene terephthalate) (PET) comprised of microfibrils with diameters of ~1 µm or nanofibrils with diameters of 50-150 nm as well as microfibrillar scaffolds of poly(glycolic acid) (PGA) have been used. An extremely low initial amount of xylene has been found (< 20 ppm). The xylene amount dropped below 2 ppm after drying for 24 h in a vacuum at 80°C. The microfibrillar PGA scaffolds, initially containing more xylene (23.4 ppm), retained only 3.6 ppm after drying for 24 h. After drying for 48 h the amount of xylene in all the scaffolds studied reached the detection limits of the GC-MS apparatus (< 0.5 ppm).

• Periodical: Journal of Biomimetics, Biomaterials and Tissue Engineering (Volume 7)
• Pages: 1-6
• DOI: https://doi.org/10.4028/www.scientific.net/JBBTE.7.1
• Online since: October 2010
• Authors: A. Lederer, C. Harnisch, Debes Bhattacharyya, S. Fakirov
• Keywords: Fibrillar Scaffolds, Microfibril, Nanofibrils, Organic Solvent Traces, Tissue Engineering

References

[1] Hollister, S., Natural Materials, 2005. 4: p.518.

[2] Karageorgiou, V., and Kaplan, D., Biomaterials, 2005. 26: p.5474.

[3] Langer, R., and Vacanti, J., Tissue engineering. Science, 1993. 260: p.920.

[4] Yang, S., Leong, K., Du, Z., and Chua, C., Tissue Engineering, 2001. 7: p.679.

[5] Pham, Q., Sharma, U., and Mikos, A., Biomacromolecules, 2006. 7: p.2796.

[6] Murugan, R., and Ramakrishna, S., Tissue Engineering, 2007. 13: p.1845.

[7] Greiner, A., and Wendorff, J., Angewandte Chemie-International Edition, 2007. 46: p.5670.

[8] Agarwal, S., Wendorff, J. H., and Greiner, A., Polymer, 2008. 49: p.5603.

[9] Reneker, D. H., Yarin, A. L., Zussman, E., and Xu, H., Advances in Applied Mechanics, 2007. 41: p.43.

[10] Rutledge, G., and Fridrikh, S., Advanced Drug Delivery Revues, 2007. 59: p.1384.

[11] Fakirov, S., eXPRESS Polymer Letters, 2009. 3: p.200.

[12] Fakirov, S., Bhattacharyya, D., and Shields, R. J., Colloids and Surfaces, A: Physicochemical Engineering Aspects, 2008. 313-314: p.2.

DOI: 10.1016/j.colsurfa.2007.05.038

[13] Evstatiev, M., Fakirov, S., Bechthold, G., and Friedrich, K., Advances in Polymer Technology, 2000. 19: 249.

[14] Evstatiev, M., Schultz, J. M., Fakirov, S., and Friedrich, K., Polymer Engineering and Science, 2001. 41: p.192.

[15] Shields, R. J., Bhattacharyya, D., and Fakirov, S., Journal of Material Science, 2008. 43: p.6758.

[16] Fakirov, Journal of Applied Polymer Science, 2006. 102: p. (2013).

[17] Fakirov, S., Bhattacharyya, D., and Hutmacher, D., In: Bhatnagar, N., and Srivastan, T. S., eds. Processing and Fabrication of Advanced Materials – XVII, Vol. 2, New Delhi: I. K. International Publishing House Pvt. Ltd., 2009, pp.794-803.

[18] Bhattacharyya, D., and Fakirov, S., In: Karger-Kocsis, J., and Fakirov, S., eds. Nano- and Micromechanics of Polymer Blends and Composites, Munich, Hanser, 2009, pp.167-205.

DOI: 10.3139/9783446430129.fm