Influence of Ligands on Physicochemical Characteristics of Magnetic Nanoparticles

Jaroslava Szucsova; Adriana Zelenakova; Lubos Nagy; Michael Barutiak; Eva Benova; Vladimir Zelenak; Vlasta Zavisova

doi:10.4028/p-2x4090

Paper Titles

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Influence of Ligands on Physicochemical Characteristics of Magnetic Nanoparticles
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HomeJournal of Nano ResearchJournal of Nano Research Vol. 78Influence of Ligands on Physicochemical...

Influence of Ligands on Physicochemical Characteristics of Magnetic Nanoparticles

Abstract:

Magnetic-bead separation or purification serves as a technique for effective isolation of biomolecules. In presented work we prepared and characterized core-shell magnetic nanoparticle samples consisted of Fe₃O₄ core coated with SiO₂ shell. Samples were subsequently coated with ligands MPTMS (3-(mercaptopropyl)trimethoxysilane), CPTMS (3-(chloropropyl)trimethoxysilane) and MMSP (3-(trimethoxysilyl)propyl methacrylate) with aim to increase the number of active centers for specific binding with RNA. Such samples were further investigated for their magnetic properties, size, and morphology. Magnetic properties were studied in DC field up to 5 T in temperature range 5 – 300 K. Size and morphology were determined from SEM micrographs and elemental compositions of the samples were investigated using EDX analysis. Modification of nanoparticle surface with different ligands leads to modification of active centers on the SiO₂ surface on which the DNA and RNA molecules can be bounded. It also causes the change in magnetic and structural properties of nanoparticles.

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Periodical:

Journal of Nano Research (Volume 78)

Pages:

91-96

DOI:

https://doi.org/10.4028/p-2x4090

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Online since:

April 2023

Authors:

Jaroslava Szucsova*, Adriana Zelenakova, Lubos Nagy, Michael Barutiak, Eva Benova, Vladimir Zelenak, Vlasta Zavisova

Keywords:

Biomedical Applications, Core-Shell, Magnetic Nanoparticles, Magnetic Separation, Organic Ligand, SEM

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