Biodegradation of Porous Alpha-Tricalcium Phosphate Coated with Silk Sericin
Porous a-tricalcium phosphate (a-TCP) ceramics are attractive as a novel bioresorbable material for bone repair, since they can be easily fabricated through conventional sintering of b-TCP at high temperature. However, the solubility of a-TCP is too high to keep its body until the bone defect is repaired completely. Coating of the a-TCP porous body with organic polymer is a way to reduce the degradation rate. In the present study, biodegradation of a-TCP porous body coated with silk sericin was evaluated in vivo. Bone repair at the defect made in rabbit tibia was nearly completed after 4 weeks. Higher density of cortical bone was estimated for a-TCP coated with sericin than for mere a-TCP. The a-TCP porous body coated with sericin is expected as a material that show less degradation than mere a-TCP, and may result in suitable bone repair.
Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.
A. Takeuchi et al., "Biodegradation of Porous Alpha-Tricalcium Phosphate Coated with Silk Sericin", Key Engineering Materials, Vols. 284-286, pp. 329-332, 2005