Biodegradation of Porous Alpha-Tricalcium Phosphate Coated with Silk Sericin

Abstract:

Porous a-tricalcium phosphate (a-TCP) ceramics are attractive as a novel bioresorbable material for bone repair, since they can be easily fabricated through conventional sintering of b-TCP at high temperature. However, the solubility of a-TCP is too high to keep its body until the bone defect is repaired completely. Coating of the a-TCP porous body with organic polymer is a way to reduce the degradation rate. In the present study, biodegradation of a-TCP porous body coated with silk sericin was evaluated in vivo. Bone repair at the defect made in rabbit tibia was nearly completed after 4 weeks. Higher density of cortical bone was estimated for a-TCP coated with sericin than for mere a-TCP. The a-TCP porous body coated with sericin is expected as a material that show less degradation than mere a-TCP, and may result in suitable bone repair.

• Periodical: Key Engineering Materials (Volumes 284-286)
• Pages: 329-332
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.284-286.329
• Online since: April 2005
• Authors: Akari Takeuchi, Chikara Ohtsuki, Masanobu Kamitakahara, Shinichi Ogata, Masao Tanihara, Toshiki Miyazaki, Masao Yamazaki, Yoshiaki Furutani, Hisao Kinoshita
• Keywords: Biodegradation, Coating, Porous Body, Silk Sericin, α-Tricalcium Phosphate (α-TCP)

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[10] [15] [20] [5] [10] [15] [20] [5] Bone density / mg/cm3 Area of cortical bone / % Figure 5. Density histograms of rabbit tibiae where αPB and αPB/Ser were implanted for 4 weeks.