Biodegradation of Porous Alpha-Tricalcium Phosphate Coated with Silk Sericin

Abstract:

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Porous a-tricalcium phosphate (a-TCP) ceramics are attractive as a novel bioresorbable material for bone repair, since they can be easily fabricated through conventional sintering of b-TCP at high temperature. However, the solubility of a-TCP is too high to keep its body until the bone defect is repaired completely. Coating of the a-TCP porous body with organic polymer is a way to reduce the degradation rate. In the present study, biodegradation of a-TCP porous body coated with silk sericin was evaluated in vivo. Bone repair at the defect made in rabbit tibia was nearly completed after 4 weeks. Higher density of cortical bone was estimated for a-TCP coated with sericin than for mere a-TCP. The a-TCP porous body coated with sericin is expected as a material that show less degradation than mere a-TCP, and may result in suitable bone repair.

Info:

Periodical:

Key Engineering Materials (Volumes 284-286)

Main Theme:

Edited by:

Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.

Pages:

329-332

DOI:

10.4028/www.scientific.net/KEM.284-286.329

Citation:

A. Takeuchi et al., "Biodegradation of Porous Alpha-Tricalcium Phosphate Coated with Silk Sericin", Key Engineering Materials, Vols. 284-286, pp. 329-332, 2005

Online since:

April 2005

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Price:

$35.00

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