Bone Induction by Controlled Release of BMP-2 from a Biodegradable Hydrogel in Various Animal Species - From Mouse to Non-Human Primate -
The objective of this study is to examine feasibility of biodegradable gelatin hydrogels incorporating bone morphogenetic protein (BMP)-2 in inducing bone regeneration at a bone defect of non-human primates and rabbits considering their BMP-2 release profiles. As a result, controlled release by the hydrogel system enabled BMP-2 to induce successful bone regeneration in non-human primates even at the BMP-2 dose as low as that for rabbit case (0.034 mg of BMP-2/cm3 of hydrogel).
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
M. Yamamoto et al., "Bone Induction by Controlled Release of BMP-2 from a Biodegradable Hydrogel in Various Animal Species - From Mouse to Non-Human Primate -", Key Engineering Materials, Vols. 288-289, pp. 253-256, 2005