Bone Induction by Controlled Release of BMP-2 from a Biodegradable Hydrogel in Various Animal Species - From Mouse to Non-Human Primate -

Masaya Yamamoto; Yoshitake Takahashi; Yasuhiko Tabata

doi:10.4028/www.scientific.net/KEM.288-289.253

Paper Titles

The Long Term Study of HA/TCP Biphasic Ceramics' Osteoinduction
p.237

The Influences of β-Glucan Associated with BMP-7 on MC3T3-E1 Proliferation and Osteogenic Differentiation
p.241

Successful Osteoinduction by Cell-Macroporous Biphasic HA-TCP Ceramic Matrix
p.245

A Simple but Effective Demineralizing Method for Osteogenic Allograft Preparation
p.249

Bone Induction by Controlled Release of BMP-2 from a Biodegradable Hydrogel in Various Animal Species - From Mouse to Non-Human Primate -
p.253

Fibrin-Reinforced Collagen Matrix Enhances Tissue Regeneration and Angiogenesis
p.257

The Study of Collagen-HA Composite with Incorporated BMP as Bone Tissue Engineering Scaffold
p.261

Gene Expression of C2C12 Cells on Calcium Phosphate Ceramic In Vitro
p.265

Evaluation of Gamma Irradiated Human Bone in Nude Rats
p.269

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Bone Induction by Controlled Release of BMP-2 from a Biodegradable Hydrogel in Various Animal Species - From Mouse to Non-Human Primate -

Abstract:

The objective of this study is to examine feasibility of biodegradable gelatin hydrogels incorporating bone morphogenetic protein (BMP)-2 in inducing bone regeneration at a bone defect of non-human primates and rabbits considering their BMP-2 release profiles. As a result, controlled release by the hydrogel system enabled BMP-2 to induce successful bone regeneration in non-human primates even at the BMP-2 dose as low as that for rabbit case (0.034 mg of BMP-2/cm3 of hydrogel).