In Vitro and In Vivo Evaluation of Amino Acid-Functionalized Cellulose Beads for Whole Blood Hemoperfusion

Abstract:

Article Preview

Phenylalanine linked to cellulose beads was designed as an adsorbent in whole blood hemoperfusion for the therapy of rheumatoid arthritis. In whole blood perfusion tests, the adsorbent adsorbed rheumatoid factors directly from whole blood. In vitro test showed that the adsorbent had good biocompability properties. No acute systemic toxicity and dermal irritancy with extremely low skin sensitizing activity were observed. In vivo animal test with satisfactory results was perfumed with rabbits. Experimental results show that the adsorbent holds promise as a highly effective and safe hemoadsorbent in clinical therapy for rheumatoid arthritis patients by hemoperfusion.

Info:

Periodical:

Key Engineering Materials (Volumes 288-289)

Edited by:

Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata

Pages:

393-396

Citation:

Y. J. Wang and Y. T. Yu, "In Vitro and In Vivo Evaluation of Amino Acid-Functionalized Cellulose Beads for Whole Blood Hemoperfusion", Key Engineering Materials, Vols. 288-289, pp. 393-396, 2005

Online since:

June 2005

Export:

Price:

$38.00

[1] NH He, YJ Wang, ZW Wang, et al: World J Gastroenterol Vol. 10 (2004), p.1218.

[2] M Yonekawa, M Tanaka, A Kawamura: Therapeutic Apheresis Vol. 5 (2001), p.476.

[3] D Hailey, LA Topfer: Issues Emerg Health Technol (28) 2002, p.1.

[4] GA Siami, FS Siami: International Journal of Artificial Organs Vol. 25 (2002), p.499.

[5] CW Wiesenhutter, BL Irish, JH Bertram.: J Rheumatol Vol. 21 (1994), p.804.

[6] Z Yamazaki, Y Idezuki, N Inoue, et al: Biomater Artif Cells Artif Organs Vol. 17 (1989), p.117.

[7] K Siegfried, H Manfred, G Beatrice, et al: Artificial Organ. Vol. 26 (2002), p.124.

[8] YT Yu, YJ Wang, J Wei, Patent, CN 03130403. 6.