In order to study the influence of stress ratio and WC grain size, the characteristics of fatigue crack growth were investigated in WC-Co cemented carbides with two different grain sizes of 3 and 6 µm. Fatigue crack growth tests were carried out over a wide range of fatigue crack growth rates covering the threshold stress intensity factor range DKth. It was found that crack growth rate da/dN against stress intensity factor range DK depended on stress ratio R. The crack growth rate plotted in terms of effective stress intensity factor range DKeff still exhibited the effect of microstructure. Fractographic examination revealed brittle fracture at R=0.1 and ductile fracture at R=0.5 in Co binder phase. The amount of Co phase transformation for stress ratio was closely related to fatigue crack growth characteristics.