Enhancing Bone Regeneration by Synthetic Peptide-Coated CMP Granules

D.H. Yoon; H.J. Kim; J.H. Lee; M.J. Cho; Hong In Shin

doi:10.4028/www.scientific.net/KEM.309-311.215

Paper Titles

Effects of pH on the Transformation of Gypsum to Carbonate Apatite in the Presence of Ammonium Hydrogen Phosphate
p.199

Effects of Paste Type Calcium Sulfate on the Periodontal Healing of 3-Wall Intrabony Defects in Dogs
p.203

Osteoblastic Response to Resorbed Ceramic Surfaces; The Role of the Osteoclast in Osteoconduction
p.207

Biodegradation and Characterization of Phase Separated NaCa(PO₃)₃ and KCa(PO₃)₃ from Pure Ca(PO₃)₂
p.211

Enhancing Bone Regeneration by Synthetic Peptide-Coated CMP Granules
p.215

Preparation of Submicron Biphasic α-TCP/HA Powders
p.219

Dissolution Behavior of Submicron Biphasic Tricalcium Phosphate Powders
p.223

Comparative Study of the Degradation Behavior of Mechanically Mixed and Chemically Precipitated Biphasic Calcium Phosphates
p.227

Stress Analysis and Optimizing of Osteoinductive Ca-P Ceramics and Net-Cage-Structured Titanium Alloy in Dog Segmental Femoral Defect Reparation
p.231

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Enhancing Bone Regeneration by Synthetic Peptide-Coated CMP Granules

Abstract:

For effective bone regeneration, various surface modifications have been tried. In an effort to improve osteogenic repair potential, we evaluated recombinant peptides containing the RGD domain as a bioactive molecule for tissue-engineered bone regeneration. The synthetic peptides slightly suppressed cellular proliferation in the in vitro culture system but induced favorable osteoblastic differentiation, which was determined by MTT and ALP activity staining, respectively. The synthetic peptide coated CMP granules, which were implanted into the mandibular bone defects showed more favorable bone repair compared to the non-coated CMP implantation. In addition, there were not any sign of inflammatory reaction. These findings suggest that synthesized peptides containing the RGD domain enhance cellular attachment and osteogenic activity in vivo condition and that the peptide-coated CMP granules can serve as a biocompatible bone substitute.