Preparation and Characterization of Biodegradable β-TCP-Based Composite Microspheres as Bone Tissue Engineering Scaffolds

Qing Feng Zan; Chen Wang; Li Min Dong; Rui Liu; Jie Mo Tian

doi:10.4028/www.scientific.net/KEM.336-338.1646

Paper Titles

Electrochemically Assisted Co-Precipitation of Electrically Conducting Polymer with Calcium Phosphate Coatings on Ti Alloys
p.1632

Degradation Behavior of Calcium Sulfate/β-Tricalcium Phosphate Composites in Tris
p.1635

Exploring the Osteoinductivity of Calcium Phosphate Ceramics/PLA or Collagen Composites
p.1638

Preparation of β-TCP/HAP Composite Bioceramics
p.1642

Preparation and Characterization of Biodegradable β-TCP-Based Composite Microspheres as Bone Tissue Engineering Scaffolds
p.1646

Degradation Behavior of β-Ca₃ (PO₄)₂/β-Ca₂P₂O₇ Bioceramics
p.1650

Physicochemical and Mechanical Properties of Composite of Chitosan Microspheres/Calcium Phosphate Cement
p.1654

Rheological Properties of an Injectable Calcium Phosphate Bone Cement and their Relationship with the Phase Evolution
p.1658

Repairing the Dog's Femoral Defect with the Autologous Osteoblast Integrated the Nano-Calcium Phosphate/Zirconia Scaffold
p.1662

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Preparation and Characterization of Biodegradable β-TCP-Based Composite Microspheres as Bone Tissue Engineering Scaffolds

Abstract:

Since a small globular particle was first used as support for three-dimensional (3D) growth of anchorage-dependent cells in suspended cultures, a variety of microspheres as tissue engineering scaffolds have been developed. In this paper, β-TCP and chitosan were selected as the components of microspheres due to their biodegradability and osteogenic properties. The biodegradable β-TCP/chitosan composite microspheres were prepared by a solid-in-water-in-oil (s/w/o) emulsion cross-linking method in this paper. The size distribution, surface morphology, and microstructure of the microspheres were evaluated. Scanning electron microscopy revealed that the size of the microspheres with good spherical morphology was distributed in the range of 50~200μm. In vitro immersion experiments were carried out to evaluate the degradability of the microspheres, and the results demonstrated that the chitosan/β-TCP composite microspheres were potential materials as tissue engineering scaffolds for bone repair.