The goal of this research project is the development of a simulation model for lifetime estimation of components manufactured from the AA6016-T4/FeP06 material compound. Components composed of this material are manufactured predominantly by rolling and deepdrawing. For this reason, the influence of the plastic deformations during the manufacturing process on the fatigue behaviour must be investigated. Particularly the cyclic hardening behaviour of FeP06 steel has a relevant effect on the fatigue life of this aluminium-steel compound. Simulation models for fatigue life estimation therefore have to consider the influence of this hardening effect, which occurs during the manufacturing process. In this work, test results and a simulation model to take into account the influence of the rolling reduction on the fatigue behaviour of components manufactured from the AA6016/FeP06 material compound are presented.