Several parameters and corresponding performance of reinforced concrete column cross-sections of different shapes (square, rectangular, circular, T-shape, I-shape, cross-shape, L-shape and C-shape) under various loading conditions have been studied in order to determine the suitable and optimum cross-sections for strength and ductility. In each cross-section shape, parameters include compressive strength of concrete (f’c), tensile strength of steel (fy), steel ratio (As/Ag), and angle of bending. In order to demonstrate the behavior and performance of the sections in terms of strength and ductility, CSISectionBuilder software was used to define the stress-strain curve for concrete and steel and then compute the moment-curvature relationship for each section. Considering different sections, the number of parameters in every section and various loading conditions, a total of around 1,800 sections were analyzed. The comparison procedures started within each section shape, and then across different sections in order to determine the most suitable cross-section for strength and ductility. Results of the study are deemed very useful in the system selection and preliminary design of important structures such as buildings with complicated geometry and high architectural demand including bridge piers and hydraulic structures.