An experimental investigation was undertaken into the seismic performance of a precast prestressed concrete frame system. A total of three beam-to-column connection models were designed, built, and tested to failure to evaluate their strength and ductility properties under cyclic loading. The comparative study showed that the hysteretic loops were full and the joints had better energy dissipation capacity. It was concluded that satisfactory seismic performance could be expected from this frame system if the slip of the U-shaped reinforcing steel bar was controlled well on the zone of joint. Then the finite element method (FEM) was used to analyze the specimen and the calculation results were in good agreement with those of the test.