Synthesis and Characterization of Potentially Antimicrobial Complexes of Zn(II) and Cu(II) with Chlorhexidine as Ligand
Chlorhexidine, 1,1'-hexamethylene-bis-[5-(p-chlorophenyl)-biguanide] is a clinically used antiseptic agent with a broad activity spectrum, effective against either Gram positive bacteria such as Mutans streptococcus or Gram negative bacteria such as Pseudomonas aeruginosa. It has eliminating effects on some mycobacteria. In order to prevent the loss of the biological activity caused by poor solubility of chlorhexidine and to limit the side effects of chlorhexidine when used as antiseptic, we synthesised Zn(II)- and Cu(II)- complexes of chlorhexidine, L1, as well as with chlorhexidine diacetate, L2, in 1:1 and 1:2 M:L molar ratios. Based on the elemental analysis data, IR and UV-Vis spectroscopy, and ESI-MS spectrometry we proposed the appropriate molecular formulae of the complexes.
F. Dumitru et al., "Synthesis and Characterization of Potentially Antimicrobial Complexes of Zn(II) and Cu(II) with Chlorhexidine as Ligand", Key Engineering Materials, Vol. 415, pp. 49-52, 2009