In this study, orthogonal arrays were applied in the design of the experiments and Ti6Al4V end-milling experiments were performed on the DAEWOO machining center. The white light interferometer was used to obtain the average surface roughness (Ra). A quadratic model was proposed to fit the experimental data of the surface roughness. And the fit model was used to optimize the cutting parameters in the given material removal rate. Finally the verification experiments showed good agreement with the estimated results.